Driven by rise in demand for safe and effective medicines,along with increase in rare and chronic disorders, the plasma fractionationmarket is evolving steadily

Plasma fractionation is a process employed to purify andseparate plasma into individual protein components. These fractionates are thenpurified, which can further be used as therapeutic medicines, known asplasma-derived therapies or plasma-derived medicinal products. This involves asequence of processes, including precipitation / chromatography, purification,and virus-inactivation. Plasma fractionation is a highly developed bioprocessthat can be carried out from small scale to commercial scale production. It isworth highlighting that more than 30 unique therapeutic plasma proteins havealready been developed through plasma fractionation which helps to treatvarious indications.

The global plasma fractionation market size is estimatedto grow from USD 4.80 billion in 2024 to USD 12.7 billion by 2035, representinga CAGR of 9.2% during the forecast period till 2035.

Plasma-derived therapies have lowered the healthcareexpenditures that are incurred during hospitalization and have contributed tosocio-economic gains. Hence, they are being increasingly adopted for treatmentof a myriad of disease indications. The list of plasma-derived products alongwith the information on therapeutic applications have been mentioned below:

§  Albumin:Acute Respiratory Distress Syndrome, Burns, Cardiopulmonary Bypass,Hemodialysis, Hypoalbuminemia, Hypovolemia (shock), Surgery and Trauma

§  Alpha-1 Proteinase InhibitorTherapies: Alpha-1Antitrypsin Deficiency

§ C1Esterase Inhibitor Therapies: Hereditary Angioedema

§ CoagulationFactors: HemophiliaA, Hemophilia B, Von Willebrand Disease and Antithrombin III Deficiency

§ Immunoglobulins:PrimaryImmunodeficiency Disease (PID), Chronic Inflammatory DemyelinatingPolyneuropathy (CIDP), Idiopathic Thrombocytpenic Purpura (ITP) and KawasakiDisease.

During our research, we identified more than 35 players thatare engaged in blood plasma fractionation.

Most of the plasma fractionation facilities are located inEurope (97%). This is followed by plasma fractionation facilities located inAsia-Pacific (94%) and North America (46%). It is worth highlighting thatAegros (Israel), Grifols (Egypt) and Kamada (Israel) have plasma fractionationfacilities located in the rest of the world.

97% of the plasma is fractionated to produceimmunoglobulins, this is followed by albumins (94%) and coagulation factors(86%). It is worth highlighting that 30 firms are involved in fractionatingblood plasma for the development of all of these aforementioned plasma-derivedtherapeutic products; examples of such plasma fractionation companies include(in alphabetical order, no specific selection criteria) China National BiotecGroup (CNBG), Intas Pharmaceuticals, Merck KGaA, and Oryx Bio-Tech.

Majority (74%) of the plasma fractionators are largecompanies. This can be attributed to their extensive plasma fractionationfacilities and their ability to establish a strong presence in multiple keylocations, enabling them to effectively meet the growing demand. Notableexamples of such plasma fractionation companies include (in alphabetical order,no specific selection criteria) ADMA Biologics, Biotest, GC Biopharma, andHualan Biological. Additionally, we came across 6% small players with less than50 employees; namely (in alphabetical order) CAF-DCF and Evolve Biologics.

Research Methodology

Our analysts have performed an accurate examination of thevarious aspects of the global market leveraging avant-garde primary andsecondary sources of data collection. The report has gathered the necessarydata and information from several reliable sources. Additionally, the reportoffers many strategic recommendations for companies involved in thisever-growing business sector to help them attain a competitive edge in the PlasmaFractionation Market.

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